Simonis Lab: Publications

2025

Simonis A, Theobald SJ, Koch AE, Mummadavarapu R, Mudler JM, Pouikli A, Göbel U, Acton R, Winter S, Albus A, Holzmann D, Albert MC, Hallek M, Walczak H, Ulas T, Koch M, Tessarz P, Hänsel-Hertsch R, Rybniker J. Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages. Mol Syst Biol. 2025 Apr;21(4):341-360.
Klingmüller A, Feldmann M, Rohr S, Helmhold L, Junker L, Scherer M, Vehreschild JJ, Schmidt-Hellerau K, Hoffmann A, Jantsch J, Simonis A, Suárez V, Rauschning D, Funke N, Malin JJ, Biehl LM, Schommers P, Fätkenheuer G, Lehmann C, Rybniker J, Suárez I. Clinical heterogeneity and treatment outcomes of extrapulmonary tuberculosis in a low-incidence setting: insights from a prospective cohort study. Infection. 2025 Mar 11.

Albus A, Kreer C, Klein F, Rybniker J, Simonis A. Protocol for developing Pseudomonas aeruginosa type III secretion system-neutralizing monoclonal antibodies from human B cells. STAR Protoc. 2024 Dec 20;5(4):103440.
Steinke J, Di Cristanziano V, Naendrup JH, Cadar D, Gabriel M, Grosser R, Sieg N, Altenrath L, Welters J, Simonis A, Sprute R, Garcia Borrega J, Steger G, Schmidt-Chanasit J, Shimabukuro-Vornhagen A, Gruell H. Fatal dengue virus infection in an unvaccinated traveler. Eur J Clin Microbiol Infect Dis. 2025 Mar;44(3):747-752. doi: 10.1007/s10096-024-05021-4.

Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms JA, Zuber S, Kottege L, Winter S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann AM, Meyer C, Ercanoglu MS, Cramer N, Munder A, Hallek M, Fätkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Klein F, Rybniker J.
Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.
Cell. 2023 Nov 9;186(23):5098-5113.e19.
Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, Bock F.
The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.
J Mol Cell Biol. 2023 Oct 27:mjad062.
Augustin M, Heyn F, Ullrich S, Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald SJ, Lehmann C
Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome
Front Med. 2023 Apr 24;10:1129288.

Theobald SJ*, Simonis A*, Mudler JM, Göbel U, Acton R, Kohlhas V, Albert MC, Hellmann AM, Malin JJ, Winter S, Hallek M, Walczak H, Nguyen PH, Koch M, Rybniker J.
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination
EMBO Mol Med. (2022);14(8):e15888.
Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer
Cancer Lett. 2022 Jul 10;538:215697.

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