Simonis Lab

Publications

2023

  • Simonis A, Kreer C, Albus A, Rox K, Yuan B, Holzmann D, Wilms JA, Zuber S, Kottege L, Winter S, Meyer M, Schmitt K, Gruell H, Theobald SJ, Hellmann AM, Meyer C, Ercanoglu MS, Cramer N, Munder A, Hallek M, Fätkenheuer G, Koch M, Seifert H, Rietschel E, Marlovits TC, van Koningsbruggen-Rietschel S, Klein F, Rybniker J. 
    Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa.
    Cell. 2023 Nov 9;186(23):5098-5113.e19.
  • Hamdorf M, Imhof T, Bailey-Elkin B, Betz J, Theobald SJ, Simonis A, Di Cristanziano V, Gieselmann L, Dewald F, Lehmann C, Augustin M, Klein F, Alcazar MAA, Rongisch R, Fabri M, Rybniker J, Goebel H, Stetefeld J, Brachvogel B, Cursiefen C, Koch M, Bock F. 
    The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.
    J Mol Cell Biol. 2023 Oct 27:mjad062. 
  • Augustin M, Heyn F, Ullrich S, Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald SJ, Lehmann C
    Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome
    Front Med. 2023 Apr 24;10:1129288.

2022

  • Theobald SJ*, Simonis A*, Mudler JM, Göbel U, Acton R, Kohlhas V, Albert MC, Hellmann AM, Malin JJ, Winter S, Hallek M, Walczak H, Nguyen PH, Koch M, Rybniker J.
    Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination
    EMBO Mol Med. (2022);14(8):e15888.
  • Taromi S, Firat E, Simonis A, Braun LM, Apostolova P, Elze M, Passlick B, Schumacher A, Lagies S, Frey A, Schmitt-Graeff A, Burger M, Schmittlutz K, Follo M, von Elverfeldt D, Zhu X, Kammerer B, Diederichs S, Duyster J, Manz MG, Niedermann G, Zeiser R.
    Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer
    Cancer Lett. 2022 Jul 10;538:215697.

2021

  • Theobald SJ*, Simonis A*, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Albert MC, Chhen J, Motameny S, Erger F, Fischer J, Malin JJ, Gräb J, Winter S, Pouikli A, David F, Böll B, Koehler P, Vanshylla K, Gruell H, Suárez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J
    Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19
    EMBO Mol Med (2021);13(8):e14150.
  • Simonis A*, Russkamp NF*, Mueller J, Wilk CM, Wildschut MHE, Myburgh R, Wildner-Verhey van Wijk N, Mueller R, Balabanov S, Valk PJM, Theocharides APA, Manz MG
    Disruption of CSF-1R signaling inhibits growth of AML with inv(16)
    Blood Adv. 2021 Mar 9;5(5):1273-1277.
  • Simonis A, Theobald SJ, Fätkenheuer G, Rybniker J, Malin JJ
    A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2
    EMBO Mol Med. 2021 Jan 11;13(1):e13105
  • Eisfeld HS, Simonis A, Winter S, Chhen J, Ströh LJ, Krey T, Koch M, Theobald SJ, Rybniker J
    Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages
    Viruses (2021);13(10):2076.
  • Sörgel F, Malin JJ, Hagmann H, Kinzig M, Bilal M, Eichenauer DA, Scherf-Clavel O, Simonis A, El Tabei L, Fuhr U, Rybniker J
    Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent haemodialysis
    J Antimicrob Chemother. 2021 Feb 11;76(3):825-827.

2020

  • von Ambüren J, Schreiber F, Fischer J, Winter S, van Gumpel E, Simonis A*, Rybniker J*
    Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium 
    Microorganisms (2020);8(8):1096.
  • Myburgh R, Kiefer JD, Russkamp NF, Magnani CF, Nuñez N, Simonis A, Pfister S, Wilk CM, McHugh D, Friemel J, Müller AM, Becher B, Münz C, van den Broek M, Neri D, Manz MG
    Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells
    Leukemia 2020 Oct;34(10):2688-2703.

2018

  • Simonis A, Fux M, Nair G, Mueller NJ, Haralambieva E, Pabst T, Schmid JP, Schmidt A, Schanz U, Manz MG, Müller AMS
    Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency – a case report and comprehensive review of the literature
    Ann Hematol. 2018 Jun 13.
  • Simonis A, Schubert-Unkmeir A
    The role of acid sphingomyelinase and modulation of sphingolipid metabolism in bacterial infection
    Biol Chem. 2018 Jun 1.

2016

  • Simonis A, Schubert-Unkmeir A
    Interactions of meningococcal virulence factors with endothelial cells at the human blood-cerebrospinal fluid barrier and their role in pathogenicity
    FEBS Lett. 2016 Nov;590(21):3854-3867.

2014

  • Simonis A, Hebling S, Gulbins E, Schneider-Schaulies S, Schubert-Unkmeir A
    Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells
    PLoS Pathog. 2014 Jun 12; 10(6):e1004160
Simonis Lab

Center for Molecular Medicine Cologne (CMMC)
Department I of Internal Medicine
University Hospital of Cologne
Robert-Koch-Str. 21
50931 Cologne
Germany

ag-simonis[@]uk-koeln.de
+49 221 89614 / +49 221 89609
www.simonis-lab.cmmc-uni-koeln.de

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Center for molecular medicine Cologne
University of Cologne University of Cologne University Hospital of Cologne